RESEARCH INTERESTS

The design, synthesis, and discovery of anticancer agents have been the core of my scientific endeavors for the past 25 years. Design of new compounds is normally preceded by computational calculations based on the structure and activity of known agents in the cancer armamentarium. Discovery of new agents is an ongoing process with sources often derived from plants. New biological materials have been brought from the South American Rain Forest.
 

EDUCATION

-B.S. Chemistry and Pharmacy 1974, National University, Bogota, Colombia Thesis: Psidium Caudatum: Phytochemical Studies.

-M.S. Organic Chemistry 1983, Wichita State University, Wichita, KS. Thesis: Ring Expansion of Aziridinones.

-Ph.D. Organic Chemistry 1986, Wayne State University, Detroit, MI. Dissertation : Electron Transfer Photooxygenation of Sterically Strained Heterocycles. Minor: Analytical Chemistry.

EXPERIENCE

1991-  Director Research and Natural Products. Walker Cancer Research Inst. Detroit, MI.

Synthesis and in-vitro evaluation of new anticancer and anti-AIDS agents. Evaluation, isolation and characterization of anticancer and antiviral agents from natural products(plants). Development of methods for biological testing.

1992-  Lecturer Wayne State University Detroit, MI

Teaching of General Chemistry at all levels, Organic and Bioorganic Chemistry.

1986-90  Researcher and postdoctoral fellow. Michigan Cancer Foundation, Detroit, MI.

Synthesis of new nucleosides analogues as anti-AIDS agents. Synthetic modifications of steroids as probes to map receptor characteristics in breast cancer. Computer-aided molecular modeling in drug design.

1981-85  Graduate Research Assistant Wayne State University and Wichita State University.

Research in Synthetic Organic Chemistry and Photochemistry. New methods for the synthesis of oxiranes, aziridines and peroxides. Extensive use of analytical intrumentation (NMR, Fluorimetry, GC, HPLC, UV, IR, etc.).

1975-80  Director Social Security Pharmacy. Bogotá, Colombia.

Management of personnel and drugstores. Compilation of drug standards.
 

PUBLICATIONS

Palomino E., Calderon E. Estudio fitoquímico del aceite esencial de Psidium caudatum McVaugh. Revista Colombiana de Ciencias Químico-Farmaceúticas. 3, 57-74, 1977.

Schaap, P; Palomino E. Cosensitized Electron-Transfer Photooxygenation of Epoxides. J. of Photochemistry , 25, 167, 1984.

Schaap, P; Palomino E. The Photochemical Preparation of Ozonides by Electron - Transfer Photo-Oxygenation of Epoxides. Tetrahedron., 41, 2229, 1985.

Talaty, E.; Palomino, E. et al. Reaction of Aziridinones with Thiourea: A Novel Synthesis of Specifically Substituted Glycocyamidines and Hydantoins. Synth. Comm 17(9), 1063, 1987.

Palomino, E.; Kessel, D.; Horwitz, J. P. A Dihydropyridine Carrier System for Sustained Delivery of 2', 3'-Dideoxynucleosides to the Brain. J. Med. Chem. 32, 622, 1989.

Palomino, E.; Schaap, P.; Heeg, M.J. Strained Oxiranes from cis-Diols. Tetrahedron Lett. 30, 6797, 1989.

Palomino, E.; Schaap, P.; Heeg, M.J. Photooxygenation of Strained Epoxides. Tetrahedron Lett. 30, 6801, 1989.

Palomino, E. Nucle-sidos antivirales para el tratamiento del SIDA. Revista Colombiana de Ciencias Químico-Farmaceúticas. 17, 21-24, 1989.

Palomino, E.; Meltsner, B.R.; Kessel, J.P.; Horwitz, J.P. Synthesis and Evaluation of Some 4-Thiopyrimidine -2,3-Dideoxynucleosides for Prevention or Reversing AIDS - Associated Neurological Disorders. J.Med. Chem. 33, 258, 1990.

Palomino, E.; Heeg, M.J.; Horwitz, J.P.; Brooks, S.C. Binding, X-Ray and NMR Studies of the Three A-ring Isomers of Natural Estradiol. J. Steroid. Biochem.. 35, 219-229, 1990.

Palomino, E. Delivery of Drugs Through Dihydropyridine Carriers. Drugs of the Future. 15, 361-368, 1990

Palomino, E.; Schaap, P.; Rahman, A.M.; Heeg, M.J. The Structure of b (+) - (1R,2S,3R,4S) - (2-endo,3-endo-Diphenyl) - Bornane-2, 3 -Ozonide. Acta Cryst.. C46, 1942-1944, 1990.

Palomino, E.; Schaap, P.; Rahman, A.M.; Heeg, M.J. The Structure of (+) - (1R,2S,3R,4S) - (2-endo,3-endo-Diphenyl) - 2, 3 - Epoxybornane. Acta Cryst.. C46, 1940- 1942, 1990.

Palomino, E. A-Ring Substituted Steroids. Drugs of the future. 15, 909-918, 1990.

Palomino, E. Steroids 90-91: From Sex Hormones to Plant Regulators. Current Patents. 1419-1431, October 1991.

Palomino E. Walker E. H., Blumenthal S.L. Carbohydrate prodrugs: Potential use for in situ activation and drug delivery. Drugs of the future. 16, 1029-1037, 1991.

Palomino, E.; Kessel, J.P.; Horwitz, J.P. A dihydropyridine carrier system for delivery of 2',3'- dideoxycytidine (DDC) to the brain. Nucleosides & Nucleotides. 11, 1639-1649,1992.

Palomino, E. Agentes sustantivos, viscosantes y estabilizadores de espuma: Alcanolamidas grasas y sus congeneres. Arte y Ciencia Cosmetica . 7, 4-8, 1992.

Palomino, E. Liberaci-n de F?rmacos a travZs de O-Glic-sidos. Revista Colombiana de Ciencias Químico-Farmaceúticas. 20, 5-8, 1992.

Maldonado, C.; Palomino, E.; Reguero, M.T. Evaluaci-n de cinco compuestos esteroidales en la linea celular MCF-7 y en larvas de Artemia salina. Revista Colombiana de Ciencias Químico-Farmaceúticas. 21, 52-59, 1993.

Palomino, E." Carbohydrate Handles" as Natural Resources in Drug Delivery. Adv. Drug Del. Rev. 13, 311-323, 1994.

Palomino, E.; Heeg, M.J.; Horwitz, J.P.; Polin, L.; Brooks, S.C. Skeletal conformations and receptor binding in some 9,11-modified estradiols J. Steroid. Biochem. 50, 75-84, 1994.

Palomino, E.; Maldonado C.; Kempff M.B.; Ksebati M.B. Caparratriene, an Active Sesquiterpene Hydrocarbon from Ocotea Caparrapi (Nates) Dugand. J. Nat. Prod. 59, 77-79, 1996.

Palomino, E.; Foster B.J.; Kempff, M.B. Wiegand, R.; Horwitz, J.P., Baker, L.H. Evidence for metabolism of 9-methoxy-N,N-dimethyl-5-nitropyrazole [3,4,5-kl] acridine-2(6H) propanamine. J. Drug Metab. Dispos. 38, 453-458, 1996.

Palomino, E.; Foster B.J.; Kempff, M.B. Wiegand, R.; Horwitz, J.P., Baker, L.H. Evidence for metabolism of 9-methoxy-N,N-dimethyl-5-nitropyrazole [3,4,5-kl] acridine-2(6H) propanamine. J. Drug Metab. Dispos. 38, 453-458, 1996.

Palomino, E.; Heeg, M.J.; Brooks, S.C. Crystal Structure, Receptor Binding and Gene Regulation of 2- and 4- nitro Estradiols. Implications of Hydrophobic close fit in activity. Steroids 61, 670- 676, 1996.

Palomino, E. "Chemical Modulation of Activity in Steroidal Estrogens" in Biochemistry and Function of Sterols, ch. 18. CRC Press. Boca Raton. 245 - 256, 1997.

Wiese,T.E, Polin, L.A, Palomino, E., Brooks, S.C. Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17b: a 3D QSAR study. J. Med. Chem. 40, 3659-3669, 1997.

Palomino, E. "Implications of receptor binding in the steroid receptor superfamily" Curr. Opinion Drug Disc.& Dev. 1, 218-222, 1998.